Aspirin treatment reduces platelet resistance to deformation.

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Aspirin treatment reduces platelet resistance to deformation.

The present investigation has evaluated the influence of aspirin, its constituents, and other nonsteroidal anti-inflammatory agents on the resistance of human platelets to aspiration into micropipettes. Aspirin increased the length of platelet extensions into the micropipette over the entire negative tension range of 0.04 to 0.40 dynes/cm after exposure to the drug in vitro or after ingestion o...

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The aspirin resistance controversy: clinical entity or platelet heterogeneity?

In acute coronary syndromes, rupture or fissuring of the atherosclerotic plaque exposes the subendothelium and lipid core, which leads to platelet adhesion and activation. Although the most commonly used inhibitor of this process is aspirin, information about its limitations has grown over the past decade. Because the absolute risk of recurrent vascular events among patients treated with aspiri...

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Aspirin and platelet function

1 Freyssinet JM. Cellular microparticles: what are they bad or good for? J Thromb Haemost 2003; 1: 1655–62. 2 JyW,MaoWW,Horstman LL, Tao J, AhnYS. Platelet microparticles bind, activate and aggregate neutrophils in vitro. Blood Cells Molecules Dis 1995; 21: 217–31. 3 Jy W, Horstman LL, Arce M, Ahn YS. Clinical significance of platelet microparticles in autoimmune thrombocytopenias. J Lab Clin M...

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Platelet function testing for aspirin resistance is reasonable to do: yes!

When discussing the issue of aspirin resistance and platelet function testing, there are a number of databased conclusions that I believe we can agree on: (1) Aspirin resistance is a real phenomenon. There are dozens of studies and a number of meta-analyses that show on average 15% to 25% of individuals will be aspirin-resistant (ie, lack of the anticipated antiplatelet response when taking asp...

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Aspirin Resistance

The development of adverse cardiovascular events despite aspirin use has established an interest in a possible resistance to the drug. Several definitions have been set and various laboratory testing modalities are available. This has led to a wide range of prevalence reports in different clinical entities. The etiologic mechanism has been related to clinical, genetic, and other miscellaneous f...

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ژورنال

عنوان ژورنال: Arteriosclerosis: An Official Journal of the American Heart Association, Inc.

سال: 1987

ISSN: 0276-5047

DOI: 10.1161/01.atv.7.4.385